Reaktion #71205

ord-650719a08f054d818bc4d60827cf5ec9

Reaktionsgleichung

CC1(c2ccc(Cn3ncc(N)n3)s2)OCCO1
2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine
Cc1cccc(-c2oc(C)nc2C(=O)O)c1
2-methyl-5-m-tolyl-oxazole-4-carboxylic acid
→
CC(=O)c1ccc(Cn2ncc(NC(=O)c3nc(C)oc3-c3cccc(C)c3)n2)s1
2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-thiophen-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-amide

Edukte

CC1(c2ccc(Cn3ncc(N)n3)s2)OCCO1
2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine
Cc1cccc(-c2oc(C)nc2C(=O)O)c1
2-methyl-5-m-tolyl-oxazole-4-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure A followed by B, starting from 2-[5-(2-methyl-[1,3]dioxolan-2-yl)-thiophen-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine and 2-methyl-5-m-tolyl-oxazole-4-carboxylic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536209B2uspto-grants-2013_09