Reaktion #7120

Reaktionsgleichung

cis-2-Aminocyclohexanecarboxylic acid methyl ester

ammonium hydroxide

→

cis-2-aminocyclohexanecarboxylic acid amide

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction was concentrated to dryness in vacuo
2. 2
   Sonstigeazeotroped with toluene (50 mL)
3. 3
   SonstigeThe crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification

Vorschrift

cis-2-Aminocyclohexanecarboxylic acid methyl ester (2.20 g, 14.0 mmol) was treated with aqueous ammonium hydroxide (40 mL) in toluene (40 mL) and stirred vigorously at room temperature for 16 h. The reaction was concentrated to dryness in vacuo and azeotroped with toluene (50 mL). The crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification: 1H NMR (400 MHz, DMSO-d6) δ 7.78 (2 H, s br), 7.67 (s, 1 H), 7.25 (s, 1 H), 1.87 (m, 2 H), 1.60 (m, 4 H), 1.41 (m, 4 H).

Quelle