Reaktion #711754

ord-2aa29ec68eb54e4c833c549bb99b1f4d

Reaktionsgleichung

Cn1c(=O)c2c(-c3ccccc3)n(CC(C)(C)O)cc2n(C)c1=O
6-(2-hydroxy-2-methylpropyl)-1,3-dimethyl-5-phenyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
O=Cc1ccc(Cl)o1
5-chlorofuran-2-carbaldehyde
→
Cn1c(=O)c2c(-c3ccccc3)n3c(c2n(C)c1=O)C(c1ccc(Cl)o1)OC(C)(C)C3
title compound
Cn1c(=O)c2c(-c3ccccc3)n3c(c2n(C)c1=O)C(c1ccc(Cl)o1)OC(C)(C)C3
10-(5-Chlorofuran-2-yl)-1,3,8,8-tetramethyl-5-phenyl-7,8-dihydro-1H-pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazine-2,4(3H,10H)-dione

Edukte

Cn1c(=O)c2c(-c3ccccc3)n(CC(C)(C)O)cc2n(C)c1=O
6-(2-hydroxy-2-methylpropyl)-1,3-dimethyl-5-phenyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
O=Cc1ccc(Cl)o1
5-chlorofuran-2-carbaldehyde

Reagenzien

Keine

Lösungsmittel

Cc1ccccc1
toluene

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 6-(2-hydroxy-2-methylpropyl)-1,3-dimethyl-5-phenyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione and commercially available 5-chlorofuran-2-carbaldehyde in toluene analogously to Example 12, step 2;

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09303035B2uspto-grants-2016_04