Reaktion #710503

ord-09beeee2505841458329c4dc2d85ed28

Reaktionsgleichung

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

Edukte

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

Reagenzien

Keine

Lösungsmittel

O
water
O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigereaction
  2. 2
    Sonstigefor the reaction
  3. 3
    SonstigeCarbon dioxide is evaporated rapidly
  4. 4
    Sonstigewater is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    SonstigeThe product is then dried
  7. 7
    Sonstigecrushed to fine particles
  8. 8
    Sonstigeto produce an active composition suitable for formulation into the pharmacological formulations of this invention

Vorschrift

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09301935B2uspto-grants-2016_04