Reaktion #710482

Reaktionsgleichung

2-chloro-5-chloromethyl pyridine

2-aminopyridine

→

1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride

Ausbeute 86.9%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONDMF was distilled off under reduced pressure, acetonitrile
2. 2
   workup.ADDITIONwas added
3. 3
   Sonstigeto precipitate a solid
4. 4
   Sonstigethe solid was collected
5. 5
   Waschenwashed well with acetonitrile
6. 6
   Sonstigedried

Vorschrift

3.00 g (18.6 mmol) of 2-chloro-5-chloromethyl pyridine was dissolved in 20 ml of anhydrous DMF, 1.75 g (18.6 mmol) of 2-aminopyridine was added thereto, and the resulting mixture was stirred at 80° C. for 8 hours and at room temperature for 5 hours. After the reaction was completed, DMF was distilled off under reduced pressure, acetonitrile was added thereto to precipitate a solid, and the solid was collected, washed well with acetonitrile and then dried to obtain 2.07 g (yield 44%) of 1-[(6-chloropyridin-3-yl)methyl]pyridin-2(1H)-imine hydrochloride.

Quelle