Reaktion #710481

Reaktionsgleichung

2-chloro-5-chloromethyl pyridine

2-aminopyrimidine

→

1-((6-chloropyridin-3-yl)methyl)pyrimidin-2(1H)-imine hydrochloride

Ausbeute 34.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas returned to room temperature
2. 2
   workup.DISTILLATIONto distill off DMF under reduced pressure
3. 3
   workup.ADDITIONDiethyl ether was added
4. 4
   Sonstigethus crystallization
5. 5
   Sonstigewas occurred on the wall surface of an eggplant flask
6. 6
   SonstigeDiethyl ether was removed by decantation
7. 7
   Sonstigedried well

Vorschrift

300 mg (1.86 mmol) of 2-chloro-5-chloromethyl pyridine was dissolved in 6 ml of anhydrous DMF, 118 mg (1.24 mmol) of 2-aminopyrimidine was added thereto, and the resulting mixture was stirred at 80° C. for 8 hours. After the reaction was completed, the reaction solution was returned to room temperature to distill off DMF under reduced pressure. Diethyl ether was added thereto, and thus crystallization was occurred on the wall surface of an eggplant flask. Diethyl ether was removed by decantation and dried well to obtain 1-((6-chloropyridin-3-yl)methyl)pyrimidin-2(1H)-imine hydrochloride. Amount obtained 107 mg (yield 34%)

Quelle