Reaktion #710462

Reaktionsgleichung

dimethyl sulfate

2-amino-3-methyl-5-chlorobenzoic acid

potassium carbonate

sodium chloride

→

2-amino-3-methyl-5-chlorobenzoic acid methyl ester

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereacted at 110° C. for 7 hours
2. 2
   Temperaturcooled to room temperature
3. 3
   Extraktionextracted with acetate ethyl
4. 4
   Trocknendried over anhydrous sodium sulfate
5. 5
   Filtrationfiltered
6. 6
   Sonstigethe solvent was removed

Vorschrift

To a 500 mL round-bottom flask, 0.2 mol of 2-amino-3-methyl-5-chlorobenzoic acid having the structural formula of IV-5, 300 mL of DMF and 2.0 grams of potassium carbonate were added, stirred at room temperature for 0.5 hour, dimethyl sulfate was dripped, reacted at 110° C. for 7 hours, and cooled to room temperature, poured into a saturated sodium chloride solution, extracted with acetate ethyl, dried over anhydrous sodium sulfate, filtered and the solvent was removed to obtain a crude product, 35.2 grams of 2-amino-3-methyl-5-chlorobenzoic acid methyl ester having a structural formula of VIII-3 was obtained by column chromatography, and the yield was 88.4%;

Quelle