Reaktion #71016

Reaktionsgleichung

K2CO3

4-nitro-2H-[1,2,3]triazole

5-chloromethyl-furan-2-carboxylic acid methyl ester

N2

bromide

→

title compound

5-(4-Nitro-[1,2,3]triazol-2-ylmethyl)-furan-2-carboxylic acid methyl ester

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed under reduced pressure, water (50 mL)
2. 2
   workup.ADDITIONwas added
3. 3
   Extraktionthe product was extracted with EA (3×30 mL)
4. 4
   Trocknenextracts were dried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Sonstigethe solvents were removed under reduced pressure
7. 7
   SonstigePurification of the residue by FC (50:50 hept-EA)

Vorschrift

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 4-nitro-2H-[1,2,3]triazole (1.50 g, 13.15 mmol) in acetone (26.3 mL) was treated with 5-chloromethyl-furan-2-carboxylic acid methyl ester (2.66 g, 14.47 mmol) followed by K2CO3 (9.18 g, 65.75 mmol) and TBA bromide (848 mg, 2.63 mmol). The reaction mixture was stirred at rt overnight. The solvent was removed under reduced pressure, water (50 mL) was added and the product was extracted with EA (3×30 mL) and the combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (50:50 hept-EA) gave the title compound as a yellow oil: TLC:rf (50:50 hept-EA)=0.22. LC-MS-conditions 02: tR=0.90 min.

Quelle