Reaktion #709816

ord-b3600f257f7b4adca0aeb8ea61d082c8

Reaktionsgleichung

O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1
Z-Phe-OH
CCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-norLeu-OH
C[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-Ala-OH
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-Val-OH
CSCC[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-Met-OH
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-Leu-OH
→
COC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C
H-Val-Pro-OMe

Edukte

O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1
Z-Phe-OH
CCCC[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-norLeu-OH
C[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-Ala-OH
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-Val-OH
CSCC[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-Met-OH
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)O
Z-Leu-OH

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Instead of Z-Ala-OH, (a) Z-Val-OH, (b) Z-Leu-OH, (c) Z-Phe-OH, (d) Z-Met-OH and (e) Z-norLeu-OH were used as starting compounds to obtain (a') H-Val-Pro-OMe, (b') H-Leu-Pro-OH, (c') H-Phe-Pro-OH, (d') H-Met-Pro-OMe and (e') H-norLeu-Pro-OMe as oils, respectively.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04772587uspto-grants-1988_09