Reaktion #709515

Reaktionsgleichung

hydrochloric acid

4-t-amyl-2-chlorophenol

sodium hydroxide

ethyl 2-bromooctanoate

→

2-(4-t-Amyl-2-Chlorophenoxy)Octanoic Acid

Lösungsmittel

water

water

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefor 3 hours
2. 2
   workup.ADDITIONwas added
3. 3
   SonstigeThe organic layer was separated
4. 4
   Waschenwashed twice with water
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Einengenconcentrated under reduced pressure
7. 7
   Sonstigeto obtain 55 g of an oily substance

Vorschrift

A mixture of 37.2 g of 4-t-amyl-2-chlorophenol, 200 ml of toluene, and 20.4 g of sodium hydroxide was heated to 80° C., and 40.3 g of ethyl 2-bromooctanoate was added dropwise thereto over a period of one hour, followed by reacting the mixture at that temperature for 3 hours. After cooling the mixture with water, 300 ml of water was added thereto, and 40 ml of concentrated hydrochloric acid was dropwise added. The organic layer was separated, washed twice with water, dried over magnesium sulfate, and concentrated under reduced pressure to obtain 55 g of an oily substance.

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