Reaktion #70944

Reaktionsgleichung

2-(trifluoromethyl)pyridine-3-carbothioamide

1-[3,4-bis(benzyloxy)-5-nitrophenyl]-2-bromoethanone

→

4-(3,4-bis(benzyloxy)-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)thiazole

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthe reaction mixture was poured onto water (50 mL)
2. 2
   FiltrationThe resulting precipitate was filtered off
3. 3
   Waschenwashed with water (25 mL)
4. 4
   Sonstigedried
5. 5
   SonstigeRecrystallisation from dichloromethane/isopropanol

Vorschrift

A mixture of 2-(trifluoromethyl)pyridine-3-carbothioamide (0.227 g, 1.10 mmol) and 1-[3,4-bis(benzyloxy)-5-nitrophenyl]-2-bromoethanone (0.50 g, 1.10 mmol) were refluxed overnight in absolute ethanol (5 mL). After cooling to room temperature, the reaction mixture was poured onto water (50 mL). The resulting precipitate was filtered off, washed with water (25 mL) and dried. Recrystallisation from dichloromethane/isopropanol afforded 4-(3,4-bis(benzyloxy)-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)thiazole, 0.539 g (87%).

Quelle