Reaktion #70941

Reaktionsgleichung

hydrochloric acid

3,4-bis-benzyloxy-5-nitro-benzonitrile

sodium azide

ammonium chloride

→

5-(3,4-bis-benzyloxy-5-nitro-phenyl)-2H-tetrazole

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to room temperature
2. 2
   workup.ADDITIONthe reaction mixture was poured onto water (30 mL)
3. 3
   SonstigeThe resulting precipitate was collected
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried

Vorschrift

A mixture of 3,4-bis-benzyloxy-5-nitro-benzonitrile (0.54 g, 1.50 mmol), sodium azide (0.15 g, 2.25 mmol) and ammonium chloride (0.12 g, 2.25 mmol) in dimethylformamide (3 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (30 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 5-(3,4-bis-benzyloxy-5-nitro-phenyl)-2H-tetrazole, 0.53 g (87%).

Quelle