Reaktion #709268

Reaktionsgleichung

2-methyl-8a-morpholino-3-nitro-4-(2-trifluoromethylphenyl)-4a,5,6,7,8,8a-hexahydro-4H-chromene

ammonia

hydrochloric acid

→

2-Methyl-3-nitro-4-(2-trifluoromethylphenyl)-1,4,5,6,7,8-hexahydroquinoline

Lösungsmittel

ethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted twice with 10 ml of chloroform each time
2. 2
   SonstigeAfter the chloroform has been evaporated off
3. 3
   Sonstigethe residue crystallizes in yellow crystals from a little ethanol

Vorschrift

2 g (4.7 mmol) of 2-methyl-8a-morpholino-3-nitro-4-(2-trifluoromethylphenyl)-4a,5,6,7,8,8a-hexahydro-4H-chromene are suspended in 15 ml of ethanol and dissolved with about 3 ml of concentrated aqueous ammonia solution at 30° to 45° C. The pH is then brought to 3 with concentrated hydrochloric acid and the solution is diluted with 5 ml of water and extracted twice with 10 ml of chloroform each time. After the chloroform has been evaporated off, the residue crystallizes in yellow crystals from a little ethanol.

Quelle