Reaktion #709266

ord-322e4f1e9fcb482d876007b595fc1c6a

Reaktionsgleichung

CCOC(=O)CC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(=O)c1ccccc1
ethyl 3-nitrobenzylidenebenzoylacetoacetate
C1CCC(N2CCOCC2)CC1
morpholinocyclohexane
CCO
ethanol
→
CCOC(=O)C1=C(c2ccccc2)OC2(N3CCOCC3)CCCCC2C1c1cccc([N+](=O)[O-])c1
Ethyl 8a-morpholino-4-(3-nitrophenyl)-2-phenyl-4a,5,6,7,8,8a-hexahydro-4H-chromene-3-carboxylate

Edukte

CCOC(=O)CC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(=O)c1ccccc1
ethyl 3-nitrobenzylidenebenzoylacetoacetate
C1CCC(N2CCOCC2)CC1
morpholinocyclohexane
CCO
ethanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturunder reflux for 4 hours
  2. 2
    EinengenThe solution is concentrated
  3. 3
    Sonstigethe residue is triturated with ether
  4. 4
    Filtrationfiltered off with suction
  5. 5
    Sonstigerecrystallized from ethanol

Vorschrift

A solution of 10.9 g (0.033 mole) of ethyl 3-nitrobenzylidenebenzoylacetoacetate and 5.6 g (0.033 mole) of morpholinocyclohexane in 80 ml of ethanol is boiled under reflux for 4 hours. The solution is concentrated and the residue is triturated with ether, filtered off with suction and recrystallized from ethanol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04769375uspto-grants-1988_09