Reaktion #707369

Reaktionsgleichung

2-(4-benzylpiperidino)-1-chloro ethane

sodium amide

ether

3,4-dichlorophenylacetonitrile

→

oily product

Ausbeute 69.0%

4-(4-benzylpiperidino)-2-(3,4-dichlorophenyl)butyronitrile

Ausbeute 69.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is heated for 2 hours
2. 2
   Temperaturto reflux
3. 3
   Temperaturheating
4. 4
   Temperaturto reflux
5. 5
   TemperaturThe resulting mixture is cooled
6. 6
   Sonstigeafter what the organic phase is decanted
7. 7
   Waschenwashed with water
8. 8
   Extraktionextracted with a 10% solution of hydrochloric acid
9. 9
   Extraktionextracted with ether
10. 10
    Waschenwashed with water
11. 11
    Trocknendried over magnesium sulfate
12. 12
    Sonstigeevaporated

Vorschrift

1.95 g of sodium amide are added in small quantities to an ether solution of 9.3 g of 3,4-dichlorophenylacetonitrile. The mixture is heated for 2 hours to reflux, 11.8 g of 2-(4-benzylpiperidino)-1-chloro ethane are added and heating is repeated for another 5 hours to reflux. The resulting mixture is cooled and 200 ml of water are added, after what the organic phase is decanted, washed with water and extracted with a 10% solution of hydrochloric acid. The aqueous phase is then neutralized with soda, extracted with ether, washed with water, dried over magnesium sulfate and evaporated. 13 g of oily product are thus obtained.

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