Reaktion #707219

Reaktionsgleichung

1-phenyl-2-chloromethyl-5-chloro-6-ethylbenzimidazole

4-aminopyridine

acetone

→

compound

Ausbeute 29.8%

1-phenyl-2-(4-pyridylaminomethyl)-5-chloro-6-ethylbenzimidazole hydrochloride

Ausbeute 29.8%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 1.5 hours
2. 2
   Filtrationthe mixture was filtered
3. 3
   Einengenthe filtrate was concentrated in vacuo
4. 4
   Sonstigerecrystallized from ethanol

Vorschrift

A mixture of 1-phenyl-2-chloromethyl-5-chloro-6-ethylbenzimidazole (1.7 g, 5.5 mmol) prepared in the preceding step (b), 4-aminopyridine (1.8 g, 10.3 mmol) and ethanol (10.8 ml) was refluxed for 1.5 hours, then the mixture was filtered and the filtrate was concentrated in vacuo and crystallized from acetone (1.0 g, 2.35 mmol) and recrystallized from ethanol, then the objective compound (0.35 g, 0.82 mmol) was obtained.

Quelle