Reaktion #70655

Reaktionsgleichung

water

6-hydrazino-3-phenyl-1,5-naphthyridin-2(1H)-one

ethyl difluoroacetate

difluoroacetic acid

→

1-(difluoromethyl)-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7(6H)-one

Lösungsmittel

DMI

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe resulting solid was collected by filtration

Vorschrift

A mixture of 6-hydrazino-3-phenyl-1,5-naphthyridin-2(1H)-one (7-2) (21 g, 83 mmol), ethyl difluoroacetate (31 g, 250 mmol), and difluoroacetic acid (200 mg, 2.08 mmol) in DMI (100 mL) was heated under microwave irradiation at 200° C. for 1 h. To the cooled mixture was added water, and the resulting solid was collected by filtration to give 1-(difluoromethyl)-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7(6H)-one (10-1) as pale yellow solid.

Quelle