Reaktion #70638

Reaktionsgleichung

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate

HCl

→

1-(trifluoromethyl)cyclopropylamine hydrochloride

Ausbeute 91.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 3.5 h
2. 2
   EinengenThe solution was concentrated in vacuo
3. 3
   Sonstigethe residue was triturated with acetone
4. 4
   SonstigeThe filtrate was collected
5. 5
   Einengenconcentrated
6. 6
   Sonstigethe residue triturated with diethyl ether

Vorschrift

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (4.08 g, 18.3 mmol) was suspended in 1 N HCl(aq) (150 mL) and stirred at reflux for 3.5 h. The solution was concentrated in vacuo and the residue was triturated with acetone. The filtrate was collected, concentrated, and the residue triturated with diethyl ether to afford 2.67 g (91%) of 1-(trifluoromethyl)cyclopropylamine hydrochloride as a white solid.

Quelle