Reaktion #706303

Reaktionsgleichung

6-amino-4-(2-chloroethyl)-2(1H)-quinolone hydrochloride

4-(1-piperazinyl)thieno[3,2-c]pyridine

sodium bicarbonate

→

6-amino-4-[2-[4-(thieno[3,2-c]pyridin-4-yl)-1-piperazinyl]ethyl]-2(1H)-quinolone hydrochloride

Lösungsmittel

dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to room temperature
2. 2
   Extraktionthe crude product is extracted with chloroform
3. 3
   TrocknenThe organic phase is dried over sodium sulpbate
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe crude product is purified by flash chromatography on silica
6. 6
   Wascheneluting first with a methanol/ethyl acetate (6.5:93.5) mixture
7. 7
   workup.ADDITIONcontaining traces of triethylamine

Vorschrift

A mixture of 0.35 g (1.35 mmol) of 6-amino-4-(2-chloroethyl)-2(1H)-quinolone hydrochloride, 0.33 g (1.5 mmol) of 4-(1-piperazinyl)thieno[3,2-c]pyridine and 0.17 g (2 mmol) of sodium bicarbonate in 10 ml of dimethylformamide is heated to 60° C. for 24 hours. After cooling to room temperature, the reaction medium is diluted in 50 ml of water and the crude product is extracted with chloroform. The organic phase is dried over sodium sulpbate and concentrated. The crude product is purified by flash chromatography on silica, eluting first with a methanol/ethyl acetate (6.5:93.5) mixture containing traces of triethylamine and then with a methanol/dichloromethane (6.5:93.5) mixture comprising traces of aqueous ammonia.

Quelle