Reaktion #706261

Reaktionsgleichung

2-bromo-1-(2-benzyloxy-phenyl)-ethanone

thiourea

→

4-(2-Benzyloxy-phenyl)-thiazol-2-ylamine hydrobromide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated to a volume of 60 ml
2. 2
   Sonstige20.7 g of 4-(2-benzyloxy-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals
3. 3
   workup.ADDITIONafter the addition of 250 ml of diethyl ether

Vorschrift

A solution of 21.7 g of 2-bromo-1-(2-benzyloxy-phenyl)-ethanone in 150 ml of methanol was treated at room temperature with 7.6 g of thiourea and boiled for 1 hour. The reaction mixture was concentrated to a volume of 60 ml. 20.7 g of 4-(2-benzyloxy-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 250 ml of diethyl ether.

Quelle