Reaktion #70622

Reaktionsgleichung

Na2CO3

4-bromo-2-(trifluoromethyl)benzene-1-sulfonyl chloride

4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide

→

4-Aminomethyl-N-tert-butyl-2-trifluoromethyl-benzenesulfonamide

Reaktionsbedingungen

Vorschrift

4-Aminomethyl-N-tert-butyl-2-trifluoromethyl-benzenesulfonamide was synthesized in a manner analogous to 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide in Example 4, using 4-bromo-2-(trifluoromethyl)benzene-1-sulfonyl chloride in place of 4-bromo-3-methylbenzene-1-sulfonyl chloride. In the second step, K4-[Fe(CN)6].3H2O was used in place of Zn(CN)2, Pd(OAc)2/dppf was used as the catalyst, Na2CO3 was used as base and the reaction mixture was stirred at 110° C. with microwave irradiation for one hour.

Quelle