Reaktion #70611

Reaktionsgleichung

3-amino-6-chloro-pyridine-2-carboxylic acid amide

potassium carbonate

4-fluorophenylboronic acid

→

3-amino-6-(4-fluorophenyl)picolinamide

Ausbeute 92.0%

Lösungsmittel

DMF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeSolvents were removed
2. 2
   workup.ADDITION1N HCl (30 ml) was added to the mixture
3. 3
   FiltrationThe resulting solid was filtered

Vorschrift

A mixture of 3-amino-6-chloro-pyridine-2-carboxylic acid amide (2 g), potassium carbonate (3.2 g), tetrakis(triphenylphosphine) palladium (0.674 g) and 4-fluorophenylboronic acid (1.79 g) in DMF (50 mL) and water (10 mL) was heated to 120° C. for 16 hours. Solvents were removed and 1N HCl (30 ml) was added to the mixture. The resulting solid was filtered to provide 2.48 g of 3-amino-6-(4-fluorophenyl)picolinamide which was characterized by its mass spectrum as follows: MS (m/z) 232 [M+H]+.

Quelle