Reaktion #70581

Reaktionsgleichung

5-(1-benzyl-5-phenyl-1H-imidazol-2-yl)-2-phenylpyrimidine

5-(1-benzyl-2-phenyl-1H-imidazol-5-yl)-2-phenylpyrimidine

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title compound

2-phenyl-5-(5-phenyl-1H-imidazol-2-yl)pyrimidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared by the method

Vorschrift

The title compound was prepared by the method described in Example 1, Step D, except that 5-(1-benzyl-5-phenyl-1H-imidazol-2-yl)-2-phenylpyrimidine (this Example, Step B) was used instead of 5-(1-benzyl-2-phenyl-1H-imidazol-5-yl)-2-phenylpyrimidine. The title compound was isolated as a white solid (0.044 g, 62% yield); Rf 0.26 with 95:5 v/v dichloromethane-methanol; melting point 238° C.; 1H-NMR (400 MHz; DMSO-d6) δ 9.40 (s, 2H), 8.43 (m, 2H), 7.99-7.84 (m, 2H), 7.58-7.20 (m, 8H); MS (ESI+) m/z 299.1 (M+1); H-PGDS FPBA IC50: 2.8 μM.

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