Reaktion #70570

Reaktionsgleichung

ethyl 1-benzylpiperidine-4-carboxylate

sodium hydroxide

→

title intermediate

sodium 1-benzylpiperidine-4-carboxylate

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeMost of the ethanol was removed under reduced pressure
2. 2
   workup.STIRRINGstirring
3. 3
   workup.WAITwas continued for six hours
4. 4
   workup.ADDITIONToluene was added
5. 5
   Sonstigeto remove most of the water by azeotrope
6. 6
   Sonstigethe material was dried under high vacuum overnight

Vorschrift

To a solution consisting of ethyl 1-benzylpiperidine-4-carboxylate (500 mg, 2.02 mmol) in ethanol (10 mL) was added 1 N sodium hydroxide (2.02 mL, 2.02 mmol) and the reaction mixture was stirred at room temperature overnight. Most of the ethanol was removed under reduced pressure and stirring was continued for six hours. Toluene was added to remove most of the water by azeotrope and the material was dried under high vacuum overnight to provide the title intermediate as a white solid.

Quelle