Reaktion #705401

Reaktionsgleichung

2-methyl-3-aminophenol

Cesium carbonate

bromoacetonitrile

→

(2-methyl-3-aminophenoxy)acetonitrile

Ausbeute 79.0%

Lösungsmittel

methylethylketone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through a coarse fritted funnel
2. 2
   WaschenThe solids were washed with ethylacetate (2×100 ml)
3. 3
   Einengenthe combined washings and filtrate were concentrated at reduced pressure

Vorschrift

2-methyl-3-aminophenol (20.1 g, 0.163 mol) was dissolved in methylethylketone (MEK) (150 ml). Cesium carbonate (106 g, 0.326 mmol) was added in portions followed by dropwise addition of bromoacetonitrile (29.3 g, 0.245 mol) over 30 min. The mixture was stirred 14 hr at room temperature, then filtered through a coarse fritted funnel. The solids were washed with ethylacetate (2×100 ml) and the combined washings and filtrate were concentrated at reduced pressure to give 20.8 g (79% yield) of (2-methyl-3-aminophenoxy)acetonitrile which required no further purification.

Quelle