Reaktion #705341

Reaktionsgleichung

ester

Methyl 4-(Pyridin-4-yl)butyrate

NaOH

HCl

→

acid 10-5

4-(Pyridin-4-yl)butanoic acid

Lösungsmittel

CH3OH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenfollowed by concentration
2. 2
   workup.DISSOLUTIONThe residue was dissolved in CHCl3
3. 3
   Trocknendried (MgSO4)
4. 4
   Einengenconcentrated

Vorschrift

A solution of ester 10-4 (10.0 g, 56 mmol), 1N NaOH (84 ml, 84 mmole) and CH3OH (200 ml) was stiffed at ambient temperature for 1.0 h. Concentrated HCl (7.0 ml, 84 mmol) was added followed by concentration. The residue was dissolved in CHCl3, dried (MgSO4) and concentrated to give acid 10-5 as a yellow solid.

Quelle