Reaktion #705340

Reaktionsgleichung

diester

Methyl 2-(methoxycarbonyl)-4-(pyridin-4-yl)butyrate

H2O

NaCl

DMF

→

ester

Methyl 4-(Pyridin-4-yl)butyrate

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with sat. NaHCO3, brine
2. 2
   Trocknendried (MgSO4)
3. 3
   Einengenconcentrated

Vorschrift

A solution of diester 10-3 (19.0 g, 80.1 mmol), H2O (1.45 ml, 80.1 mmol), NaCl (10.5 g, 160.2 mmol) and DMF was heated to 170° C. for 18 h. The reaction was diluted with EtOAc and then washed with sat. NaHCO3, brine, dried (MgSO4) and concentrated. Flash chromatography (silica, 60% EtOAc/hexanes) afforded ester 10-4 as a brown oil.

Quelle