Reaktion #70510

Reaktionsgleichung

3-Cyano-benzoic acid

3-piperidin-4-yl-1H-indole

HBTU

HOBt

DIPEA

→

3-[4-(1H-Indol-3-yl)-piperidine-1-carbonyl]-benzonitrile

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe reaction was stirred at RT for 3 hours
2. 2
   SonstigeThe organic solvent is removed under the reduced pressure
3. 3
   Sonstigethe residue is purified by a silica gel flash column

Vorschrift

3-Cyano-benzoic acid (0.09 g, 0.6 mmol) is dissolved in 3 ml of DMF, then HBTU (0.28 g, 0.75 mmol), HOBt (0.10 g, 0.75 mmol) and DIPEA (0.26 g, 2.0 mmol) are added. The mixture is stirred at RT for 20 min before adding the 3-piperidin-4-yl-1H-indole (0.09 g, 0.6 mmol). The reaction was stirred at RT for 3 hours, monitored with LC/MS. The organic solvent is removed under the reduced pressure and the residue is purified by a silica gel flash column using heptane and ethyl acetate as the elutes.

Quelle