Reaktion #704974

Reaktionsgleichung

1-(4,7-difluoronaphth-1-yl)-4-methylpentane-1,3-dione

guanidine carbonate

→

2-amino-4-(4,7-difluoronaphth-1-yl)-6-isopropylpyrimidine

Ausbeute 34.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was cooled to room temperature
2. 2
   Sonstigedirectly purified by column chromatography

Vorschrift

1-(4,7-difluoronaphth-1-yl)-4-methylpentane-1,3-dione (0.114 g, 0.5 mmol) was combined with guanidine carbonate (0.180 g, 0.5 mmol) and heated to 150° C. for 6 hours. The reaction was cooled to room temperature and directly purified by column chromatography to give 2-amino-4-(4,7-difluoronaphth-1-yl)-6-isopropylpyrimidine (0.052 g, 34%), m.p. 103-105° C.

Quelle