Reaktion #704768

Reaktionsgleichung

2-amino-2-(2-(2-benzyloxyphenyl)ethyl)pentanol

→

compound

Ausbeute 129.0%

2-Acetamido-2-(2-(2-benzyloxyphenyl)ethyl)pentyl acetate

Ausbeute 129.0%

Lösungsmittel

methylene chloride

triethylamine

acetyl chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   WaschenThe organic layer was washed with a dilute hydrochloric acid
3. 3
   Trocknenan aqueous sodium hydrogencarbonate solution and a saturated brine and dried over magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled away under reduced pressure

Vorschrift

To a solution of 2-amino-2-(2-(2-benzyloxyphenyl)ethyl)pentanol (1.1 g) in methylene chloride (35 ml), triethylamine (1.2 ml) and acetyl chloride (0.5 ml) were added and the mixture was stirred at room temperature for 6 hours. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The organic layer was washed with a dilute hydrochloric acid, an aqueous sodium hydrogencarbonate solution and a saturated brine and dried over magnesium sulfate. The solvent was distilled away under reduced pressure and the residue was subjected to silica gel chromatography (eluent; hexane-ethyl acetate=1:1) to give the subject compound (0.90 g).

Quelle