Reaktion #70378

ord-a861e7c5eaf84d5489ac58f3837896e1

Reaktionsgleichung

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17,17-bis(ethylendioxy)-6-(E)-methoxyiminoandrostane

C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CCC(=O)CC12

6-methyleneandrostane-3,17-dione

→

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title compound

Ausbeute 70.0%

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6-(E)-Methoxyiminoandrostane-3,17-dione

Ausbeute 70.0%

Edukte

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17,17-bis(ethylendioxy)-6-(E)-methoxyiminoandrostane

6-methyleneandrostane-3,17-dione

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
WaschenThe combined organic extracts were washed with H2O
2
Trocknendried over Na2SO4
3
Sonstigeevaporated to dryness

Vorschrift

The title compound II-ao was prepared in 70% yield from 3,3:17,17-bis(ethylendioxy)-6-(E)-methoxyiminoandrostane by the procedure described above for the preparation of 6-methyleneandrostane-3,17-dione (II-ac, Prepn. 13). The combined organic extracts were washed with H2O, dried over Na2SO4 and evaporated to dryness. 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 3.78 (3H, s), 3.37 (1H, dd), 2.68-1.14 (19H, m), 1.01 (3H, s), 0.98 (3H, s).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536160B2uspto-grants-2013_09