Reaktion #70368

Reaktionsgleichung

6α-carboxyandrostane-3,17-dione

NH3

→

title compound

6α-Carbamoylandrostane-3,17-dione

Lösungsmittel

toluene

SOCl2

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturwas cooled at 0° C.
3. 3
   workup.STIRRINGAfter stirring overnight at room temperature
4. 4
   Sonstigethe mixture was evaporated to dryness
5. 5
   workup.ADDITIONThe residue was treated with CH2Cl2 and H2O
6. 6
   Extraktionextracted with CH2Cl2
7. 7
   WaschenThe combined organic extracts were washed with 10% K2CO3 solution, brine
8. 8
   Trocknendried over Na2SO4
9. 9
   Sonstigeevaporated to dryness
10. 10
    SonstigeThe residue was purified by flash chromatography (SiO2, n-hexane/acetone 50/50)

Vorschrift

To a stirred suspension of 6α-carboxyandrostane-3,17-dione (1.20 g) in dry toluene (12 mL), SOCl2 (1.2 mL) was added. After stirring 5.5 h at 85° C. the solution was cooled at 0° C. and 2M NH3 solution in THF (6 mL) was added. After stirring overnight at room temperature, the mixture was evaporated to dryness. The residue was treated with CH2Cl2 and H2O and extracted with CH2Cl2. The combined organic extracts were washed with 10% K2CO3 solution, brine, dried over Na2SO4 and evaporated to dryness. The residue was purified by flash chromatography (SiO2, n-hexane/acetone 50/50) to give the title compound II-af (720 mg, 60%). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 7.27 (1H, bs), 6.78 (1H, bs), 2.50-0.72 (21H, m), 1.00 (3H, s), 0.80 (3H, s).

Quelle