Reaktion #70339

Reaktionsgleichung

residue

Methyl 2-(2-(2-chlorophenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate

NaOH

→

expected product

Ausbeute 81.0%

2-(2-(2-Chlorophenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoic acid

Ausbeute 81.0%

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was evaporated
2. 2
   Sonstigethe solid obtained
3. 3
   Extraktionextracted with CHCl3
4. 4
   SonstigeThe crude mixture was purified over a SiO2 eluting with DCM/MeOH 2%

Vorschrift

The solid residue obtained in step A was dissolved in methanol (3 ml) and aqueous solution 2N NaOH (1 ml) was added. The mixture was heated at 60° C. for 2 hours, the solvent was evaporated and the solid obtained was suspended in water. The pH was taken to 6.5 and extracted with CHCl3. The crude mixture was purified over a SiO2 eluting with DCM/MeOH 2% affording 0.170 g (yield 81%) of the expected product.

Quelle