Reaktion #70330

ord-3b57758fd6614679a9a60fa13dd81082

Reaktionsgleichung

Brc1cnc(I)nc1
5-bromo-2-iodopyrimidine
OB(O)c1ccccc1C(F)(F)F
2-(trifluoromethyl)phenylboronic acid
→
FC(F)(F)c1ccccc1-c1ncc(Br)cn1
5-bromo-2-(2-(trifluoromethyl)phenyl)pyrimidine
Ausbeute 52.0%

Edukte

—
Intermediate 21
Brc1cnc(I)nc1
5-bromo-2-iodopyrimidine
OB(O)c1ccccc1C(F)(F)F
2-(trifluoromethyl)phenylboronic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeObtained (52% yield)

Vorschrift

Obtained (52% yield) following the procedure described in Intermediate 21, starting with 5-bromo-2-iodopyrimidine and 2-(trifluoromethyl)phenylboronic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536165B2uspto-grants-2013_09