Reaktion #70312

ord-ffd306596ef8463987e9e68d2ef78b8c

Reaktionsgleichung

Nc1ccc(Br)nc1
6-bromopyridin-3-amine
OB(O)c1ccccc1C(F)(F)F
2-(trifluoromethyl)phenylboronic acid
→
Nc1ccc(-c2ccccc2C(F)(F)F)nc1
6-(2-(Trifluoromethyl)phenyl)pyridin-3-amine
Ausbeute 59.0%

Edukte

—
Intermediate 27
Nc1ccc(Br)nc1
6-bromopyridin-3-amine
OB(O)c1ccccc1C(F)(F)F
2-(trifluoromethyl)phenylboronic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeObtained (2.05 g, yield 59%)

Vorschrift

Obtained (2.05 g, yield 59%) following the procedure described in Intermediate 27, starting with 6-bromopyridin-3-amine, 2-(trifluoromethyl)phenylboronic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536165B2uspto-grants-2013_09