Reaktion #70302

Reaktionsgleichung

5-bromo-2-iodopyrimidine

2-fluorophenylboronic acid

K2CO3

→

expected product

Ausbeute 71.4%

5-Bromo-2-(2-fluorophenyl)pyrimidine

Ausbeute 71.4%

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated
2. 2
   Extraktionthe solid residue was extracted between water and ethyl acetate
3. 3
   SonstigeThe organic phase was evaporated
4. 4
   Sonstigethe crude residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate

Vorschrift

A mixture of 5-bromo-2-iodopyrimidine (2.58 mmol, 0.500 g), 2-fluorophenylboronic acid (3.87 mmol, 0.542 g), 2M aqueous solution of K2CO3 (7.76 mmol, 3.9 ml), Pd(PPh3)4 in dioxane (12 ml) was heated at 110° C. overnight. The solvent was evaporated and the solid residue was extracted between water and ethyl acetate. The organic phase was evaporated and the crude residue was purified by chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 0.466 g (yield 56%) of the expected product.

Quelle