Reaktion #70300

Reaktionsgleichung

2,5-dibromopyridine

3-fluoro-4-(tributylstannyl)pyridine

→

expected product

Ausbeute 62.0%

5-Bromo-3′-fluoro-2,4′-bipyridine

Ausbeute 62.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated
2. 2
   Extraktionthe crude mixture was extracted between water and ethyl acetate
3. 3
   SonstigeThe solid residue was purified by chromatography over SiO2 eluting with DCM/methanol

Vorschrift

In a schlenck tube, a mixture of 2,5-dibromopyridine (2.11 mmol, 0.500 g), 3-fluoro-4-(tributylstannyl)pyridine (2.32 mmol, 0.896 g), PdCl2(PPh3)2 (0.21 mmol, 0.148 g), CuI (0.43 mmol, 0.080 g) in DMF (5 ml) was heated at 130° C. for 12 hours, under argon atmosphere. The solvent was evaporated and the crude mixture was extracted between water and ethyl acetate. The solid residue was purified by chromatography over SiO2 eluting with DCM/methanol mixtures affording 0.330 g (yield 62%) of the expected product.

Quelle