Reaktion #70276

Reaktionsgleichung

methyl 2-amino-5-bromobenzoate

cyclopropylboronic acid

K3PO4

P(Cy)3

→

expected product

Ausbeute 88.3%

Methyl 2-amino-5-cyclopropylbenzoate

Ausbeute 88.3%

Lösungsmittel

toluene

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered through celite
2. 2
   Sonstigethe organic phase was separated
3. 3
   Sonstigeevaporated

Vorschrift

In a schlenck tube, a mixture of methyl 2-amino-5-bromobenzoate (43.47 mmol, 10 g), cyclopropylboronic acid (112.92 mmol, 9.700 g), K3PO4 (144.16 mmol, 30.6 g), Pd(AcO)2 (3.47 mmol, 0.780 g), P(Cy)3 (7.85 mmol, 2.2 g) in toluene (170 ml) and water (10 ml) was heated for 2 hours at 100° C., under nitrogen atmosphere. The reaction mixture was filtered through celite and the organic phase was separated and evaporated affording 7.34 g (yield 77%) of the expected product.

Quelle