Reaktion #70272

Reaktionsgleichung

3-bromo-5-nitropyridin-2-ol

POBr3

PBr3

→

expected product

Ausbeute 73.0%

2,3-dibromo-5-nitropyridine

Ausbeute 73.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with DCM
2. 2
   SonstigeThe crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate

Vorschrift

A mixture of 3-bromo-5-nitropyridin-2-ol, POBr3 and PBr3 was heated at 120° C. for 3.5 h. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The crude mixture was purified by flash chromatography over SiO2 eluting with hexane/ethyl acetate mixtures affording 2.63 g (yield 73%) of the expected product.

Quelle