Reaktion #70259

Reaktionsgleichung

5-nitro-3-phenylpyridin-2-ol

POBr3

PBr3

→

expected product

Ausbeute 62.0%

2-Bromo-5-nitro-3-phenylpyridine

Ausbeute 62.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with DCM
2. 2
   SonstigeThe organic phase was dried
3. 3
   Sonstigeevaporated

Vorschrift

A mixture of 5-nitro-3-phenylpyridin-2-ol (4.63 mmol, 1 g), POBr3 (4.74 mmol, 0.45 ml) and PBr3 (4.71 mmol, 1.4 g) was heated at 120° C. for 3.5 hours. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The organic phase was dried and evaporated affording 0.8 g (yield 62%) of the expected product.

Quelle