Reaktion #70226

Reaktionsgleichung

7-Hydroxy-6-methoxy-1-tetralone

(4-nitrobenzyl)hydroxylamine hydrochloride

pyridine

ethanol

→

title compound

Ausbeute 55.0%

(E)-7-Hydroxy-6-methoxy-3,4-dihydronaphthalen-1(2H)-one O-4-Nitrobenzyl Oxime

Ausbeute 55.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solid obtained on work
2. 2
   Sonstigeup was recrystallised (isopropanol)

Vorschrift

7-Hydroxy-6-methoxy-1-tetralone (105 mg, 0.55 mmol) was subjected to reaction with (4-nitrobenzyl)hydroxylamine hydrochloride (122 mg, 0.60 mmol) in ethanol (5 mL) and pyridine (0.5 mL, 6.45 mmol) under the same conditions as described for (E)-6,7-dimethoxy-3,4-dihydronaphthalen-1(2R)-one O-4-nitrobenzyl oxime. The solid obtained on work up was recrystallised (isopropanol) to yield the title compound (103 mg, 55%) as off-white crystals, m.p. 125-127° C.

Quelle