Reaktion #70217

Reaktionsgleichung

Acetophenone

3′-Hydroxy-4′-methoxyacetophenone

O-(4-cyanobenzyl)hydroxylamine hydrochloride

→

CP30283

Ausbeute 51.0%

(E)-3′-Hydroxy-4′-methoxyacetophenone O-4-Cyanobenzyl Oxime

Ausbeute 51.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter being heated for 3 h the reaction mixture
2. 2
   Temperaturwas cooled
3. 3
   Sonstigethe solvent removed under reduced pressure
4. 4
   FiltrationThe ensuing solid was filtered off
5. 5
   Waschenwashed with cold isopropanol (3.0 mL)

Vorschrift

Acetophenone 12 (30 mg, 0.181 mmol) was condensed with O-(4-cyanobenzyl)hydroxylamine hydrochloride (35) (37 mg, 0.200 mmol) according to the general procedure II-B defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The ensuing solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30283 (27 mg, 51%) as a white solid, m.p. 125.9-129.7° C.

Quelle