Reaktion #70209

Reaktionsgleichung

3′,4′-Dimethoxyacetophenone

compound 19

O-(4-Nitrobenzyl)hydroxylamine Hydrochloride

→

CP30257

Ausbeute 81.0%

(E)-3′,4′-Dimethoxyacetophenone O-4-Nitrobenzyl Oxime

Ausbeute 81.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter being heated for 3 h the mixture
2. 2
   Temperaturwas cooled
3. 3
   Filtrationthe resulting solid filtered off
4. 4
   Waschenwashed with cold isopropanol (3.0 mL)

Vorschrift

3′,4′-Dimethoxyacetophenone (23) (150 g, 0.832 mmol) was condensed with compound 19 (187 mg, 0.914 mmol) according to the general procedure II-A defined above. After being heated for 3 h the mixture was cooled and the resulting solid filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30257 (222 mg, 81%) as a white solid, m.p. 118.4-121.0° C.

Quelle