Reaktion #7016

Reaktionsgleichung

potassium hydroxide

carbonitrile

4-(4-Benzyl-5-morpholin-4-ylmethyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-carbonitrile

→

title compound

Ausbeute 85.1%

4-(4-Benzyl-5-morpholin-4-ylmethyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-carboxylic acid amide

Ausbeute 85.1%

Lösungsmittel

2-Methyl-propan-2-ol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigebefore evaporating under reduced pressure
2. 2
   SonstigeThe residue was purified by chromatography on silica gel

Vorschrift

Powdered potassium hydroxide (95 mg, 1.68 mmol) was added to a solution of the carbonitrile of example 52 (250 mg, 0.56 mmol) in 2-Methyl-propan-2-ol (10 ml). The mixture was heated at 100° C. for 18 hr before evaporating under reduced pressure. The residue was purified by chromatography on silica gel using methanol and ammonium hydroxide in dichloromethane (5:0.5:95) as eluant to give the title compound (220 mg), as a white solid

Quelle