Reaktion #70126

Reaktionsgleichung

methacrylic acid chloride

1-ethyl-4,4-difluorocyclohexanol

triethylamine

→

1-ethyl-4,4-difluorocyclohexyl methacrylate

Ausbeute 79.9%

Lösungsmittel

acetone

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA four-necked flask equipped with a stirrer
2. 2
   Sonstigeto obtain a solution
3. 3
   SonstigeA solution prepared
4. 4
   workup.ADDITIONwas added to the solution at 4° C. over 30 minutes
5. 5
   workup.STIRRINGThe mixture was stirred at 4° C. for 3 hours
6. 6
   Sonstigeto obtain a reaction mixture
7. 7
   WaschenThe reaction mixture was washed with water

Vorschrift

A four-necked flask equipped with a stirrer, a thermometer, and a dropping funnel was charged with 6.6 g (0.04 mol) of 1-ethyl-4,4-difluorocyclohexanol, 0.2 g of 4-dimethylaminopyridine, 4.9 g of triethylamine, and 20 g of acetone. The mixture was stirred to obtain a solution. A solution prepared by dissolving 4.6 g (0.044 mol) of methacrylic acid chloride in 5 g of acetone was added to the solution at 4° C. over 30 minutes. The mixture was stirred at 4° C. for 3 hours to obtain a reaction mixture. The reaction mixture was washed with water to obtain 7.42 g of 1-ethyl-4,4-difluorocyclohexyl methacrylate (hereinafter may be referred to as “compound (M-8)” ((M-8) in Table 1)). The yield of 1-ethyl-4,4-difluorocyclohexyl methacrylate with respect to 1-ethyl-4,4-difluorocyclohexanol was 78%.

Quelle