Reaktion #70093

Reaktionsgleichung

3-(2-propylpentanoyloxy)propanoic acid

1,3-O-benzylideneglycerol

triethylamine

→

solid

Ausbeute 83.0%

3-oxo-3-(2-phenyl-1,3-dioxan-5-yloxy)propyl 2-propylpentanoate

Ausbeute 83.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was washed with saturated NaHCO3 solution (1×90 ml), water (1×90 ml)
2. 2
   Trocknendried over Na2SO4
3. 3
   SonstigeThe organic solvent was removed under reduced pressure

Vorschrift

3-(2-propylpentanoyloxy)propanoic acid (2.05 g, 9.5 mmol) was dissolved in anhydrous CH2Cl2 (200 ml) under argon. 1,3-O-benzylideneglycerol (2.50 g, 13.67 mmol triethylamine (4.04 g, 40.0 mmol) and O-benzotriazol-1-yl-N,N, N′,N′-trimethyluronium hexafluorophosphate (4.2 g, 11.0 mmol) were added successively. The reaction mixture was stirred under argon for 72 h. The reaction mixture was washed with saturated NaHCO3 solution (1×90 ml), water (1×90 ml) and dried over Na2SO4. The organic solvent was removed under reduced pressure giving a pale, pink solid (2.99 g, 7.9 mmol, 83%).

Quelle