Reaktion #70040

Reaktionsgleichung

1-isocyano-2-methylpropan-2-yl methyl carbonate

1H-benzo[d]imidazol-5-amine

4-(4-methylpiperazin-1-yl)benzaldehyde

sodium tert.-butoxide

mono-tert-butyl malonate

→

1-(1H-Benzo[d]imidazol-5-yl)-5-(4-(4-methylpiperazin-1-yl)phenyl)-pyrrolidine-2,4-dione

Lösungsmittel

MeOH CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe compound was synthesized

Vorschrift

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.85 mg, 6.37 mmol), 4-(4-methylpiperazin-1-yl)benzaldehyde (1.3 g, 6.37 mmol), mono-tert-butyl malonate (1.53 g, 9.55 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (1.1 g, 7.01 mmol) in MeOH/CH2Cl2 1:1 (30 ml) with stirring for 2.5 days and sodium tert.-butoxide (0.235 g, 2.10 mmol) according to method 5.

Quelle