Reaktion #700341

Reaktionsgleichung

4-cyclohexylmethoxy acetophenone

trimethylsilyl triflate

triethylamine

[(2-isopropylphenyl)thio]propanedioic acid

→

title compound

6-[4-(Cyclohexylmethoxy)phenyl]-4-hydroxy-3-[(2-isopropylphenyl)thio]-2H-pyran-2-one

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Vorschrift

The title compound was prepared by Method A using 4-cyclohexylmethoxy acetophenone (2.0 g, 8.61 mmol), trimethylsilyl triflate (1.91 g, 8.61 mmol), triethylamine (1.74 g, 17.22 mmol), methylene chloride (20 mL), and diethyl ester of [(2-isopropylphenyl)thio]propanedioic acid (4.0 g, 12.92 mmol). m.p. 187-188° C.; 1H NMR (400 MHz, DMSO-d6) δ0.96-1.33 (m+1.24 d 11H), 1.61-1.87 (m, 6H), 3.4 (m, 1H), 3.86 (d, 2H), 6.76 (s, 1H), 6.92 (dd, 1H), 7.11 (m, 4H), 7.29 (dd, 1H), 7.81 (d, 2H).

Quelle