Reaktion #700335

Reaktionsgleichung

4-benzyloxyacetophenone

trimethylsilyl triflate

triethylamine

[(2-isopropylphenyl)thio]propanedioic acid

→

title compound

6-(4-Benzyloxyphenyl)-4-hydroxy-3-[(2-isopropyl-phenyl)thio]-2H-pyran-2-one

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Vorschrift

The title compound was prepared by Method A using 4-benzyloxyacetophenone (0.3 g, 0.675 mmol), trimethylsilyl triflate (0.15 g, 0.675 mmol), triethylamine (0.14 g, 1.35 mmol), methylene chloride (20 mL), and diethyl ester of [(2-isopropylphenyl)thio]propanedioic acid (0.210 g, 0.675 mmol). m.p. 163-165° C.; 1H NMR (400 MHz, DMSO-d6) δ1.28 (d, 6H), 3.4 (m, 1H), 5.22 (s, 2H), 6.64(s,1H), 6.92 (d, 1H), 7.06 (t, 1H), 7.11(t, 1H), 7.19 (d, 1H), 7.28 (d, 1H), 7.36 (q, 2H), 7.42 (d, 2H), 7.49 (d, 2H), 7.83 (d, 2H).

Quelle