Reaktion #700314

Reaktionsgleichung

3', 4'-dichloroacetophenone

trimethylsilyl triflate

triethylamine

[(2-isopropylphenyl)thio] propanedioic acid

→

title compound

6-(3,4-Dichlorophenyl)-4-hydroxy-3-[(2-isopropylphenyl)thio]-2H-pyran-2-one

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Vorschrift

The title compound was prepared by Method A using 3', 4'-dichloroacetophenone (2.46 g, 12.8 mmol), trimethylsilyl triflate (3.0 mL, 15.4 mmol), triethylamine (3.6 mL, 26.0 mmol), methylene chloride (30 mL), and diethyl ester of [(2-isopropylphenyl)thio] propanedioic acid (4.0 g, 12.8 mmol) m.p. 204-207° C.; 1H NMR (400 MHz, CDCl3) δ 1.33 (d, 6H), 3.55 (m, 1H), 6.71 (s, 1H), 7.00 (m, 1H), 7.08 (m, 1H), 7.20 (m, 1H), 7.30 (m, 1H), 7.56 (d, 1H), 7.69 (m, 1H), 7.74 (br, 1H), 7.98 (s, 1H).

Quelle